2-Oxo-2-(thiophen-2-yl)acetaldehyde → 3-(4-Fluoro-benzyl)-7-thiophen-2-yl-[1,2,4]triazolo[4,3-b][1,2,4]triazine
Reaktionsgleichung
O=[C:2]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)[CH:3]=O.[F:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][C:16]2[N:17]([NH2:22])[C:18]([NH2:21])=[N:19][N:20]=2)=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][C:16]2[N:17]3[N:22]=[CH:3][C:2]([C:5]4[S:6][CH:7]=[CH:8][CH:9]=4)=[N:21][C:18]3=[N:19][N:20]=2)=[CH:13][CH:12]=1Komponenten
3
Versuchsvorschrift
General procedure A was followed with the reaction of oxo-thiophen-2-yl-acetaldehyde and 5-(4-fluoro-benzyl)-[1,2,4]triazole-3,4-diamine to provide 3-(4-fluoro-benzyl)-7-thiophen-2-yl-[1,2,4]triazolo[4,3-b][1,2,4]triazine and 3-(4-fluoro-benzyl)-6-thiophen-2-yl-[1,2,4 ][triazolo 1,2,4,-b][1,2,4]triazine (example 5).
Quellen und Nachweise
- ORD-Eintrag
- ord-e930fc685e644cfeb3e55267d405ad9f
- Quelldatensatz
- uspto-grants-2006_10