1-Butanol → 2-chloro-N-(phenylmethyl)-9-(tetrahydro-3-thienyl)-9H-purin-6-amine

HRID 1244892Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1244892
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][S:13][CH2:12]2)=[C:4](Cl)[N:3]=1.C(O)CCC.[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(O)(C)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][S:13][CH2:12]2)=[C:4]([NH:29][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:3]=1

Komponenten

5

Edukt 3

HCID 2631-ButanolHCID 7504BenzylamineHCID 219229912,6-dichloro-9-(tetrahydro-3-thienyl)-9H-purine

Produkt 1

HCID 219229482-chloro-N-(phenylmethyl)-9-(tetrahydro-3-thienyl)-9H-purin-6-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
97.5 °C

Versuchsvorschrift

120 mg of the product obtained in Stage 1 above, 2 ml of butanol and 0,105 ml of benzylamine are mixed together and the reaction medium is heated to a temperature of approximately 95 to 100° C. for 10 hours. It is then left to return to ambient temperature and diluted with 5 ml of isopropanol, followed by separating, washing with 5 ml of isopropanol and drying under vacuum at approximately 30° C. In this way 132 mg of expected product is obtained in the form of white crystals.

Aufarbeitung

  1. waitIt is then left
  2. customto return to ambient temperature
  3. customby separating
  4. washwashing with 5 ml of isopropanol
  5. customdrying under vacuum at approximately 30° C

Quellen und Nachweise

ORD-Eintrag
ord-6b7b1c61bad14193abe471c172d54064
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07122669B1

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