HCID 57457971, Verbindung → HCID 57457960, Verbindung
Reaktionsgleichung
C(O[C:9]([N:11]1[CH2:15][C:14]([CH3:17])([CH3:16])[CH2:13][C@H:12]1[CH2:18]O)=O)C1C=CC=CC=1.[CH2:20]([O:27]C(N1C[C@@H](SC)C[C@H]1CO)=O)[C:21]1C=CC=CC=1>>[CH3:17][C:14]1([CH3:16])[CH2:15][N:11]2[C@H:12]([CH2:18][C:20](=[O:27])[CH2:21][CH2:9]2)[CH2:13]1Komponenten
3
Versuchsvorschrift
In a similar manner to the procedures described in Preparative Examples 12(v)′, 12(vi)′ and 12(vii)′ above, reactions were conducted in turn, using (S)-1-benzyloxycarbonyl-4,4-dimethyl-2-hydroxymethylpyrrolidine [obtained as described in Preparative Example 17(i)′ above] instead of (2S,4S)-1-benzyloxycarbonyl-2-hydroxymethyl-4-methylthiopyrrolidine, to give the title compound as a brown oil (yield: 36%).
Aufarbeitung
- customobtained