Hydantoin → 1-[(4-Methoxyphenyl)methyl]imidazolidine-2,4-dione

HRID 1245331Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1245331
[NH:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].C([O-])([O-])=O.[Cs+].[Cs+].[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20]Cl)=[CH:18][CH:17]=1>CN(C=O)C.[Cl-].[Na+].O>[CH3:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][N:1]2[CH2:5][C:4](=[O:6])[NH:3][C:2]2=[O:7])=[CH:18][CH:17]=1

Komponenten

6

Edukt 3

HCID 10006HydantoinHCID 10796Cesium carbonateHCID 699934-Methyloxybenzyl chloride

Produkt 1

HCID 219110281-[(4-Methoxyphenyl)methyl]imidazolidine-2,4-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 57417360Sodium chloride; waterLösungsmittel

Versuchsvorschrift

A mixture of imidazolidine-2,4-dione (5.01 g), Cs2CO3, and 4-methoxybenzyl chloride (8.0 mL) in DMF (250 mL) was allowed to react overnight. The reaction was added to 400 mL brine then extracted with ether. The desired product precipitated from the ether, and was collected by filtration to yield 1-(4-methoxybenzyl)-imidazolidine-2,4-dione as a white solid.

Aufarbeitung

  1. customto react overnight
  2. extractionthen extracted with ether
  3. customThe desired product precipitated from the ether
  4. filtrationwas collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-ba3e2795c759446fa485ec76e48a605a
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07125865B2

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