HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dimethylformamide → 4-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenylamino)-nicotinic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | N,N,2-Trimethylaniline | HCID 11869 | — |
| Edukt | 2-Chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinic acid | HCID 24806661 | — |
| Katalysator | Copper | HCID 23978 | — |
| Produkt | 4-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenylamino)-nicotinic acid | HCID 24806259 | — |
Reaktionsschritte
The title compound was prepared by heating 2-chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinic acid and trimethylaniline in the presence of potassium carbonate and copper in DMF. The desired product was isolated by silica gel column chromatography using 5% methanol in chloroform as solvent to give a tan solid, mp. 130–135° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07125880B1 |
| Quelldatensatz | uspto-grants-2006_10 |
| ORD ID | ord-a6c48e2ce0b44235ad3b9d9ca8e439e4 |
| Quellennotiz | uspto-grants-2006_10 |