Sodium Hydroxide → HCID 21914127, Verbindung

HRID 1246211Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1246211
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]1[C:13]1[N:17]=[C:16]([CH2:18][CH2:19][CH3:20])[NH:15][N:14]=1)(=O)C.[OH-].[Na+]>C(O)C.C(OCC)(=O)C>[CH2:18]([C:16]1[NH:15][N:14]=[C:13]([CH:5]2[CH2:6][C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[NH:4]2)[N:17]=1)[CH2:19][CH3:20]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 21914092HCID 21914092, Verbindung

Produkt 1

HCID 21914127HCID 21914127, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of the compound 91 (0.42g) in ethanol (25 ml) was treated with an aqueous NaOH solution (3 M, 25 mL) and the reaction mix was refluxed for 24 hours. The reaction was cooled, diluted with ethyl acetate, and treated with cold distilled water. The layers were separated and the aqueous fraction was extracted 5 times with ethyl acetate and the combined organic fractions were dried, concentrated and purified by preparatory column chromatography yielding 2,3-dihydro-2-(5-propyl-1H-1,2,4-triazol-3-yl)-1H-indole.

Aufarbeitung

  1. additionthe reaction mix
  2. temperaturewas refluxed for 24 hours
  3. temperatureThe reaction was cooled
  4. additiontreated
  5. distillationwith cold distilled water
  6. customThe layers were separated
  7. extractionthe aqueous fraction was extracted 5 times with ethyl acetate
  8. customthe combined organic fractions were dried
  9. concentrationconcentrated
  10. custompurified by preparatory column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-83ff8b9685f04c168eae218aeeb6cef9
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07125891B2

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