Hydrochloric Acid → 2-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)-1-ethanamine Hydrochloride

HRID 1246396Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1246396
B#B.[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:9]([CH2:18][C:19]#[N:20])[C:8]=2[CH:21]=1.Cl>O1CCCC1>[ClH:3].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:9]([CH2:18][CH2:19][NH2:20])[C:8]=2[CH:21]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6328200DiboronHCID 219172462-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)acetonitrile

Produkt 1

HCID 124121842-(5-Chloro-2-phenyl-1-benzothiophen-3-yl)-1-ethanamine Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3 eq. of diborane in tetrahydrofuran and 1 eq. of the nitrile obtained in Step D are introduced into a 100 ml round-bottomed flask, and the mixture is then heated at reflux for 2 hours. After cooling, 15 eq. of 6M HCl are added and the tetrahydrofuran is evaporated off under reduced pressure. The precipitate formed is filtered off and recrystallised.

Aufarbeitung

  1. temperaturethe mixture is then heated
  2. temperatureat reflux for 2 hours
  3. temperatureAfter cooling
  4. customthe tetrahydrofuran is evaporated off under reduced pressure
  5. customThe precipitate formed
  6. filtrationis filtered off
  7. customrecrystallised

Quellen und Nachweise

ORD-Eintrag
ord-0f9883912e44442e8e363e2ed5045b8d
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07126012B2

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