2-Propanone, 1-(acetyloxy)-3-chloro- → (2-Aminothiazol-4-yl)methyl acetate hydrochloride
Reaktionsgleichung
[C:1]([O:4][CH2:5][C:6](=O)[CH2:7][Cl:8])(=[O:3])[CH3:2].[NH2:10][C:11]([NH2:13])=[S:12]>C(O)C>[ClH:8].[C:1]([O:4][CH2:5][C:6]1[N:10]=[C:11]([NH2:13])[S:12][CH:7]=1)(=[O:3])[CH3:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 3-chloro-2-oxopropyl acetate (5 g) and thiourea (2.5 g) in ethanol (25 ml) was refluxed for 4 hours. The reaction mixture was cooled to ambient temperature and the resulting crystalline precipitate was collected by filtration and washed with ethanol (20 ml) to give (2-amino-1,3-thiazol-4-yl)methyl acetate hydrochloride (3.5 g) as white crystals.
Aufarbeitung
- temperaturewas refluxed for 4 hours
- filtrationthe resulting crystalline precipitate was collected by filtration
- washwashed with ethanol (20 ml)
Quellen und Nachweise
- ORD-Eintrag
- ord-c9cf578f9ea74b1a8ebb0463e4175ee1
- Quelldatensatz
- uspto-grants-2006_10
- Patentnummer
- US07125901B2
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