Carbonic Acid → HCID 21914754, Verbindung

HRID 1246432Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1246432
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1.N1C=CC=CC=1.[C:18](Cl)(=[O:22])[CH:19]([CH3:21])[CH3:20].C(=O)(O)O>ClCCl>[C:18]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1)(=[O:22])[CH:19]([CH3:21])[CH3:20]

Komponenten

6

Edukt 4

HCID 767Carbonic AcidHCID 1049PyridineHCID 62325Isobutyryl chlorideHCID 73216Ethyl 2-aminothiazole-4-carboxylate

Produkt 1

HCID 21914754HCID 21914754, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To an ice-cold mixture of ethyl 2-amino-1,3-thiazole-4-carboxylate (2 g) prepared in a similar manner according to Step 1 of the following Production Example 7, pyridine (1.3 ml) and dichloromethane (20 ml) was added isobutyryl chloride (0.91 ml) and stirred for 30 minutes. To the mixture was added saturated aqueous hydrogen bicarbonate (30 ml), and the organic layer was separated, dried over sodium sulfate and concentrated in vacuo. The crystalline residue was collected and washed with ethyl acetate to give ethyl 2-(isobutyrylamino)-1,3-thiazole-4-carboxylate (1.34 g).

Aufarbeitung

  1. customprepared in a similar manner
  2. customthe organic layer was separated
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe crystalline residue was collected
  6. washwashed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-198e3aca7685453ca20b8400c5f53bff
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07125901B2

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