Hydrochloric Acid → 2-Acetamido-1,3-thiazole-4-carboxylic acid

HRID 1246439Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1246439
[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([O:12]CC)=[O:11])[N:9]=1)(=[O:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([OH:12])=[O:11])[N:9]=1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 702548Ethyl 2-acetamido-1,3-thiazole-4-carboxylate

Produkt 1

HCID 8401132-Acetamido-1,3-thiazole-4-carboxylic acidAusbeute 74,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 2-(acetylamino)-1,3-thiazole-4-carboxylate (2 g), 2N sodium hydroxide (7 ml) and methanol (13 ml) was stirred at ambient temperature for 5 hours. The reaction mixture was neutralized by 1N hydrochloric acid (14 ml). The precipitated crystals were filtered and washed with water to give 2-(acetylamino)-1,3-thiazole-4-carboxylic acid (1.3 g).

Aufarbeitung

  1. filtrationThe precipitated crystals were filtered
  2. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-28b94cc069614c5d9c137cb14ca43440
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07125901B2

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