Hydrochloric Acid → 2-(acetylamino)-N-(4-aminophenyl)-1,3-thiazole-4-carboxamide hydrochloride

HRID 1246441Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1246441
[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([NH:19]C(=O)OC(C)(C)C)=[CH:15][CH:14]=2)=[O:11])[N:9]=1)(=[O:3])[CH3:2].[ClH:27]>CO.C(OCC)(=O)C>[ClH:27].[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=2)=[O:11])[N:9]=1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 21915112Tert-butyl 4-({[2-(acetylamino)-1,3-thiazol-4-yl]carbonyl)amino}phenylcarbamate

Produkt 1

HCID 219152912-(acetylamino)-N-(4-aminophenyl)-1,3-thiazole-4-carboxamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl 4-({[2-(acetylamino)-1,3-thiazol-4-yl]carbonyl}amino)phenylcarbamate (85 mg) in methanol (1 ml) was added 4N hydrogen chloride in ethyl acetate (1 ml), and the mixture was stirred at ambient temperature for 1 hour. The reaction mixture was concentrated in vacuo. The solid residue was collected and washed with ethyl acetate to give 2-(acetylamino)-N-(4-aminophenyl)-1,3-thiazole-4-carboxamide hydrochloride (70 mg).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe solid residue was collected
  3. washwashed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-e127d103b3584df5adf45e505d003e1d
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07125901B2

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