2-Nitro-5-(trifluoromethoxy)benzoic acid → 2-amino-5-(trifluoromethoxy)benzoic Acid

Beteiligte Stoffe

Reaktionsschritte

To a solution of 2-nitro-5-trifluoromethoxybenzoic acid (56.8 g, 0.23 mol; see step (i) above) in EtOH (1000 mL) was added 10% Pd/C (5.7 g). The resulting solution was flushed with H2 for 5 h, filtered through Celite® and concentrated in vacuo to give the crude sub-title compound (49.7 g, 98%) as a solid that was used in the next step without further purification.

Herkunft & Nachweise