Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate → Methyl 4-hydroxypiperidine-4-carboxylate

HRID 1246717Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1246717
C([N:8]1[CH2:13][CH2:12][C:11]([OH:18])([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[OH:18][C:11]1([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Komponenten

4

Edukt 1

HCID 12343427Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate

Produkt 1

HCID 21093366Methyl 4-hydroxypiperidine-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl 1-benzyl-4-hydroxy-4-piperidinecarboxylate in methanol was treated with Pd(OH)2 (20% on carbon, 500 mg) under a hydrogen atmosphere. The mixture was allowed to stir at room temperature for 12 hours, filtered, and the filtrate was concentrated under reduced pressure.

Aufarbeitung

  1. filtrationfiltered
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a2744ea31a0944faae072d239330c164
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07129235B2

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