HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-(Aminomethyl)-3-chlorobenzonitrile → (RS)-N-(2-chloro-4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-(Aminomethyl)-3-chlorobenzonitrile | HCID 4089788 | — |
| Edukt | (RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid | HCID 69288907 | — |
| Produkt | (RS)-N-(2-chloro-4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide | HCID 21905691 | — |
Reaktionsschritte
(RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid, described in example 66.1 was coupled with 4-aminomethyl-3-chlorobenzonitrile (CAS 202521-97-9) according to general procedure C to give (RS)-N-(2-chloro-4-cyano-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide. Light yellow oil. MS 379.2 ([M−H]−)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07129238B2 |
| Quelldatensatz | uspto-grants-2006_10 |
| ORD ID | ord-291a0b548b584663bc50a013d43e4751 |
| Quellennotiz | uspto-grants-2006_10 |