4-Aminomethyl-3-hydroxy-benzonitrile hydrochloride → (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide

HRID 1247357Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1247357
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([F:10])[C:3]=1[CH:11]([O:15][CH3:16])[C:12]([OH:14])=O.Cl.[NH2:18][CH2:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][C:21]=1[OH:28]>>[C:24]([C:23]1[CH:26]=[CH:27][C:20]([CH2:19][NH:18][C:12](=[O:14])[CH:11]([C:3]2[C:4]([F:10])=[CH:5][C:6]([O:8][CH3:9])=[CH:7][C:2]=2[F:1])[O:15][CH3:16])=[C:21]([OH:28])[CH:22]=1)#[N:25]

Komponenten

3

Edukt 2

HCID 219056834-Aminomethyl-3-hydroxy-benzonitrile hydrochlorideHCID 69288907(RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid

Produkt 1

HCID 21905527(RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide

Versuchsvorschrift

(RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid (example 66.1) was coupled with 4-aminomethyl-3-hydroxy-benzonitrile hydrochloride (example 110.2) according to general procedure C to give (RS)-N-(4-cyano-2-hydroxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide. Colorless foam. MS 361.1 ([M−H]−)

Quellen und Nachweise

ORD-Eintrag
ord-0e2f3acef41b42f4b8f8bd1ee1d87f48
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07129238B2

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