4-Aminomethyl-3-(2,2,2-trifluoro-ethoxy)-benzonitrile → (RS)-N-[4-cyano-2-(2,2,2-trifluoro-ethoxy)-benzyl]-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide

HRID 1247361

Reaktionsgleichung

Reaktionsgleichung von HRID 1247361
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([F:10])[C:3]=1[CH:11]([O:15][CH3:16])[C:12]([OH:14])=O.[NH2:17][CH2:18][C:19]1[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][C:20]=1[O:27][CH2:28][C:29]([F:32])([F:31])[F:30]>>[C:23]([C:22]1[CH:25]=[CH:26][C:19]([CH2:18][NH:17][C:12](=[O:14])[CH:11]([C:3]2[C:4]([F:10])=[CH:5][C:6]([O:8][CH3:9])=[CH:7][C:2]=2[F:1])[O:15][CH3:16])=[C:20]([O:27][CH2:28][C:29]([F:30])([F:32])[F:31])[CH:21]=1)#[N:24]

Komponenten

3

Edukt 2

HCID 219052434-Aminomethyl-3-(2,2,2-trifluoro-ethoxy)-benzonitrileHCID 69288907(RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid

Produkt 1

HCID 21904880(RS)-N-[4-cyano-2-(2,2,2-trifluoro-ethoxy)-benzyl]-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide

Versuchsvorschrift

(RS)-(2,6-Difluoro-4-methoxy-phenyl)-methoxy-acetic acid (example 66.1) was coupled with 4-aminomethyl-3-(2,2,2-trifluoro-ethoxy)-benzonitrile according to general procedure B to give (RS)-N-[4-cyano-2-(2,2,2-trifluoro-ethoxy)-benzyl]-2-(2,6-difluoro-4-methoxy-phenyl)-2-methoxy-acetamide. Colorless solid. MS 445.0 ([M+H]+)

Quellen und Nachweise

ORD-Eintrag
ord-772dc6130b07430d8c8225b489af67b2
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07129238B2

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