Methyl iodide → (RS)-[3-(tert-Butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-methoxy-acetic acid ethyl ester

HRID 1247389

Reaktionsgleichung

Reaktionsgleichung von HRID 1247389
[CH2:1]([O:3][C:4](=[O:33])[CH:5]([C:7]1[C:12]([F:13])=[CH:11][CH:10]=[C:9]([O:14][Si:15]([C:28]([CH3:31])([CH3:30])[CH3:29])([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:8]=1[F:32])[OH:6])[CH3:2].I[CH3:35]>>[CH2:1]([O:3][C:4](=[O:33])[CH:5]([C:7]1[C:12]([F:13])=[CH:11][CH:10]=[C:9]([O:14][Si:15]([C:28]([CH3:29])([CH3:31])[CH3:30])([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:8]=1[F:32])[O:6][CH3:35])[CH3:2]

Komponenten

3

Edukt 2

HCID 6328Methyl iodideHCID 69290212(RS)-[3-(tert-butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-hydroxy-acetic acid ethyl ester

Produkt 1

HCID 69291101(RS)-[3-(tert-Butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-methoxy-acetic acid ethyl ester

Versuchsvorschrift

(RS)-[3-(tert-Butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-methoxy-acetic acid ethyl ester was prepared in analogy to example 173 from (RS)-[3-(tert-butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-hydroxy-acetic acid ethyl ester and iodomethane. Yellowish oil. MS 484.2 (4, [M+]+); 427.1 (29, [M−tBu]+); 411.2 (14, [M−COOEt]+).

Quellen und Nachweise

ORD-Eintrag
ord-08273d5bbfa041e29246b075e0747686
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07129238B2

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