4-(Aminomethyl)-3,5-difluorobenzonitrile hydrochloride → (RS)-N-(4-cyano-2,6-difluoro-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-(Aminomethyl)-3,5-difluorobenzonitrile hydrochloride	HCID 21905559	—
Edukt	(RS)-(2,6-Difluoro-4-methoxy-phenyl)-ethoxy-acetic acid	HCID 21905754	—
Produkt	(RS)-N-(4-cyano-2,6-difluoro-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide	HCID 21904911	—

Reaktionsschritte

According to general procedure C 4-aminomethyl-3,5-difluoro-benzonitrile hydrochloride was reacted with (RS)-(2,6-difluoro-4-methoxy-phenyl)-ethoxy-acetic acid (example 101.3) give to (RS)-N-(4-cyano-2,6-difluoro-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide. Off-white solid. MS 397.1 ([M+H]+)

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07129238B2
Quelldatensatz	uspto-grants-2006_10
ORD ID	ord-ef5204fa7dd64e1097c278046e9185b0
Quellennotiz	uspto-grants-2006_10