13-cis-Acitretin → Acitretin

HRID 1247661

Reaktionsgleichung

Reaktionsgleichung von HRID 1247661
[CH3:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10](/[CH3:20])=[CH:11]/[CH:12]=[CH:13]/[C:14](/[CH3:19])=[CH:15]\[C:16]([OH:18])=[O:17])=[C:6]([CH3:21])[C:5]([CH3:22])=[C:4]([O:23][CH3:24])[CH:3]=1>O1CCCC1>[CH3:1][C:2]1[C:7](/[CH:8]=[CH:9]/[C:10](/[CH3:20])=[CH:11]/[CH:12]=[CH:13]/[C:14](/[CH3:19])=[CH:15]/[C:16]([OH:18])=[O:17])=[C:6]([CH3:21])[C:5]([CH3:22])=[C:4]([O:23][CH3:24])[CH:3]=1

Komponenten

3

Edukt 1

HCID 643784113-cis-Acitretin

Produkt 1

HCID 5284513AcitretinAusbeute 99,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Crude acetretin (10 g) and butylated hydroxyanisole (0.5 g) were dissolved in tetrahydrofuran (350 ml) at room temperature. The resultant solution was filtered and washed with tetrahydrofuran. The combined filtrate was concentrated under vacuum at 30–35° C. Acetone (100 ml) was added to the residue and stirred for 10 minutes at room temperature. The crystalline product so obtained was filtered, washed with acetone and dried at 25–30° C. under vacuum to obtain pure acitretin (8.2 g, assay 99.4% by HPLC).

Aufarbeitung

  1. filtrationThe resultant solution was filtered
  2. washwashed with tetrahydrofuran
  3. concentrationThe combined filtrate was concentrated under vacuum at 30–35° C
  4. additionAcetone (100 ml) was added to the residue
  5. customThe crystalline product so obtained
  6. filtrationwas filtered
  7. washwashed with acetone
  8. customdried at 25–30° C. under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d471693cc2d9406e8ddf63604ecb5683
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07129365B2

Verknüpfte Notizen

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