Hydrochloric Acid → 1H-Pyrazole-1-ethanol, 5-amino-4-nitroso-

HRID 1247787

Reaktionsgleichung

Reaktionsgleichung von HRID 1247787
[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][OH:9])[N:5]=[CH:4][CH:3]=1.Cl.[N:11](OCCC(C)C)=[O:12]>C(O)C>[NH2:1][C:2]1[N:6]([CH2:7][CH2:8][OH:9])[N:5]=[CH:4][C:3]=1[N:11]=[O:12]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 3202812-(5-amino-1H-pyrazol-1-yl)ethan-1-ol

Produkt 1

HCID 101490141H-Pyrazole-1-ethanol, 5-amino-4-nitroso-Ausbeute 51,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 5-amino-1-(2-hydroxyethyl)pyrazole (6.35 g) in a mixed solvent of ethanol (25 ml) and concentrated hydrochloric acid (0.035 ml) was added dropwise isoamyl nitrite (7.03 g). The mixture was stirred at room temperature for 17 hours. The crystalline residue was collected by filtration and dried in vacuo to give 5-amino-1-(2-hydroxyethyl)-4-nitrosopyrazole (4.0 g) as a solid.

Aufarbeitung

  1. filtrationThe crystalline residue was collected by filtration
  2. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-caef93d0f1284e4084569b09d22d8d2d
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07129232B2

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