Hydrochloric Acid → 1H-Pyrazol-5-amine,1-(2-fluoroethyl)-(9CI)

HRID 1247843Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1247843
[F:1][CH2:2][CH2:3][N:4]1[C:8]([NH:9]C=O)=[CH:7][CH:6]=[N:5]1.Cl>CO>[F:1][CH2:2][CH2:3][N:4]1[C:8]([NH2:9])=[CH:7][CH:6]=[N:5]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 85666041HCID 85666041, Verbindung

Produkt 1

HCID 219045531H-Pyrazol-5-amine,1-(2-fluoroethyl)-(9CI)Ausbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of [1-(2-fluoroethyl)-1H-pyrazol-5-yl]formamide (15.7 g) in methanol (78 ml) was added concentrated hydrochloric acid (21 ml) at room temperature. The reaction mixture was stirred for 3.5 hours and evaporated in vacuo. The residue was dissolved in ethyl acetate and washed with aqueous sodium hydrogen carbonate solution. The organic layer was dried over magnesium sulfate and concentrated in vacuo to give 1-(2-fluoroethyl)-1H-pyrazol-5-amine (12 g).

Aufarbeitung

  1. customevaporated in vacuo
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed with aqueous sodium hydrogen carbonate solution
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e8f5b1f3ed5345d3b0d33a8807d2cb7d
Quelldatensatz
uspto-grants-2006_10
Patentnummer
US07129232B2

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