Thionyl Chloride → HCID 13476542, Verbindung
Reaktionsgleichung
O[CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:14])[NH:6][C:5]1=[O:15].S(Cl)([Cl:18])=O>>[Cl:18][CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:14])[NH:6][C:5]1=[O:15]Komponenten
3
Versuchsvorschrift
A mixture of 3.6 parts of 1-(2-hydroxyethyl)-2,4(1H,3H)-quinazolinedione and 40 parts of thionyl chloride is stirred and refluxed overnight. The reaction mixture is allowed to cool to room temperature. The precipitated product is filtered off, washed with 2,2'-oxybispropane and dried, yielding 3.4 parts (86%) of 1-(2-chloroethyl)-2,4-(1H,3H)-quinazolinedione; mp. 215.3° C.
Aufarbeitung
- temperaturerefluxed overnight
- filtrationThe precipitated product is filtered off
- washwashed with 2,2'-oxybispropane
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-1a33e088436b4181a4182c949eea4794
- Quelldatensatz
- uspto-grants-1985_06
- Patentnummer
- US04522945
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