Ethylenediamine → 6-[3-bromo-4-(1,3-diazacyclopenten-2-ylamino)-phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

HRID 1248264Notizen

Reaktionsgleichung

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][C:3]=1[Br:16].CS[N:19]=[C:20]=O.[CH2:22](N)[CH2:23][NH2:24]>>[Br:16][C:3]1[CH:4]=[C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)[CH:6]=[CH:7][C:2]=1[NH:1][C:20]1[NH:19][CH2:22][CH2:23][N:24]=1

Komponenten

Edukt 3

HCID 3301Ethylenediamine

HCID 202792156-(4-Amino-3-bromophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

HCID 21933440Methylthioisocyanate

Produkt 1

HCID 132173476-[3-bromo-4-(1,3-diazacyclopenten-2-ylamino)-phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

Versuchsvorschrift

Using 6-(4-amino-3-bromophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone and methylthioisocyanate, the reaction was carried out in the same manner as described in Example 1(b) to the corresponding methylisothiuronium salt which was then reacted with ethylenediamine in the same manner as described in Example 1(c) to afford the above-identified compound. M.P. 265°-267° C. (with decomp.).

Aufarbeitung

customto afford the above-identified compound

Quellen und Nachweise

ORD-Eintrag: ord-d50973b0e1c44e6e8e8329c27575044f
Quelldatensatz: uspto-grants-1985_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04523011

Notizen zur Reaktion

Wird geladen…