4,6-Dimethyl-2-(4-nitrophenoxy)pyrimidine → 4-((4,6-Dimethylpyrimidin-2-yl)oxy)aniline

HRID 1248892

Reaktionsgleichung

Reaktionsgleichung von HRID 1248892
[N+:1]([C:4]1[CH:18]=[CH:17][C:7]([O:8][C:9]2[N:14]=[C:13]([CH3:15])[CH:12]=[C:11]([CH3:16])[N:10]=2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>O1CCOCC1.[Ni]>[NH2:1][C:4]1[CH:18]=[CH:17][C:7]([O:8][C:9]2[N:10]=[C:11]([CH3:16])[CH:12]=[C:13]([CH3:15])[N:14]=2)=[CH:6][CH:5]=1

Komponenten

5

Edukt 2

HCID 7760484,6-Dimethyl-2-(4-nitrophenoxy)pyrimidineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 7670374-((4,6-Dimethylpyrimidin-2-yl)oxy)anilineAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

24.5 g (0.1 mole) of 2-(4-nitro-phenoxy)-4,6-dimethyl-pyrimidine were dissolved in 150 ml of dioxane and subjected to exhaustive hydrogenation with hydrogen in the presence of Raney nickel under a pressure of 50 bar at a temperature between 20° and 50° C. The catalyst was then filtered off with suction and the filtrate was evaporated under reduced pressure. 20.4 g (95% of theory) of 2-(4-amino-phenoxy)-4,6-dimethylpyrimidine were obtained in the form of a solid substance.

Aufarbeitung

  1. customat a temperature between 20° and 50° C
  2. filtrationThe catalyst was then filtered off with suction
  3. customthe filtrate was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f1982e4efde24d49811c8caffc57f963
Quelldatensatz
uspto-grants-1986_12
Patentnummer
US04627871

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