methyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride → 2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid methyl ester

HRID 1249096

Reaktionsgleichung

Reaktionsgleichung von HRID 1249096
Cl.[CH2:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH2:5][C@@H:4]([C:15]([O:17][CH3:18])=[O:16])[NH:3]1.Cl.COC(=O)C(CC1C2C(=CC=CC=2)NC=1)N>>[CH2:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH2:5][CH:4]([C:15]([O:17][CH3:18])=[O:16])[NH:3]1

Komponenten

3

Edukt 2

HCID 2827264methyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochlorideHCID 12655248Methyl (3S)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylate--hydrogen chloride (1/1)

Produkt 1

HCID 1777282,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid methyl esterAusbeute 75 %

Versuchsvorschrift

In the same manner as described above (1) using DL-tryptophan methyl ester hydrochloride, there is obtained the title compound (75%) as colorless needles, m.p. 185°-187° C.

Quellen und Nachweise

ORD-Eintrag
ord-9541774035464f188ebbb9faf5c467ae
Quelldatensatz
uspto-grants-1986_12
Patentnummer
US04628057

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