Sodium Hydroxide → HCID 762190, Verbindung

HRID 1249105Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1249105
[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@@H:6]([C:17]([O:19]C)=[O:18])[NH:5]1)[CH2:2][CH3:3].[OH-].[Na+]>CO>[CH2:1]([C@H:4]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8]=2[CH2:7][C@@H:6]([C:17]([OH:19])=[O:18])[NH:5]1)[CH2:2][CH3:3]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 86741022HCID 86741022, Verbindung

Produkt 1

HCID 762190HCID 762190, VerbindungAusbeute 81,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of methyl (1RS,3RS)-cis-1-n-propyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate (1.3 g), 1N NaOH (5.5 ml) and methanol (8 ml) is stirred at room temperature for 1.5 hours. The mixture is distilled under reduced pressure to remove methanol. The residue is adjusted to pH 4 with 10% HCl, and the precipitated crystals are collected by filtration, washed with water and then dried to give the title compound (1.0 g, 81%) as colorless needles, m.p. 225°-226° C.

Aufarbeitung

  1. distillationThe mixture is distilled under reduced pressure
  2. customto remove methanol
  3. filtrationthe precipitated crystals are collected by filtration
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-830b5595f8d946fe892f1e19364044ce
Quelldatensatz
uspto-grants-1986_12
Patentnummer
US04628057

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