alpha,alpha-Diphenyl-4-piperidineethanol → HCID 13754500, Verbindung

HRID 1249565Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1249565
[C:1]1([C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(O)[CH2:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>FC(F)(F)C(O)=O>[C:1]1([C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:8][CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

3

Edukt 1

HCID 13754497alpha,alpha-Diphenyl-4-piperidineethanol

Produkt 1

HCID 13754500HCID 13754500, VerbindungAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

The title compound was prepared by dissolving 20 g of alpha,alpha-diphenyl-4-piperidineethanol in 40 mL of anhydrous trifluoroacetic acid and stirring for 15 minutes. The volatiles were removed under vacuum and the residue was partitioned between toluene and 2N sodium hydroxide solution. The organic layers were dried over sodium sulfate, evaporated, and the residue was crystallized from hexane to give 17.2 g (92%) of 4-(2,2-diphenylethenyl)piperidine, mp 98°-99° C. Anal. Calcd for C19H21N: C, 86.65; H, 8,.04; N, 5.32. Found: C, 86.35; H, 7.97; N, 5.26.

Aufarbeitung

  1. customThe title compound was prepared
  2. customThe volatiles were removed under vacuum
  3. customthe residue was partitioned between toluene and 2N sodium hydroxide solution
  4. dry with materialThe organic layers were dried over sodium sulfate
  5. customevaporated
  6. customthe residue was crystallized from hexane

Quellen und Nachweise

ORD-Eintrag
ord-f51470da66eb4c81ad5361f4ed5153f9
Quelldatensatz
uspto-grants-1986_12
Patentnummer
US04632925

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