Hydroxylamine → 6-[1-Hydroxy-2-(N-tert-butylbenzylamino)ethyl]-2-phenyl-4H-1,3-dioxino[5,4-b]pyridine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Hydroxylamine	HCID 787	—
Edukt	N-(1,1-Dimethylethyl)benzenemethanamine	HCID 76908	—
Edukt	6-(1,2-epoxyethyl)-2-phenyl-4H-1,3-dioxino[5,4-b]pyridine	HCID 13748403	—
Edukt	HCID 53930912	HCID 53930912	—
Lösungsmittel	Methanol	HCID 887	—
Produkt	6-[1-Hydroxy-2-(N-tert-butylbenzylamino)ethyl]-2-phenyl-4H-1,3-dioxino[5,4-b]pyridine	HCID 13340177	—

Reaktionsschritte

A solution of 33.0 g. (0.13 mole) 6-(1,2-epoxyethyl)-2-phenyl-4H-1,3-dioxino-[5,4-b]pyridine and 22.0 g. (0.135 mole) of N-tert-butylbenzylamine in 200 ml. of methanol was heated to the reflux temperature overnight. Upon cooling there deposited 6-[1- hydroxy-2-(N-tert-butylbenzylamino)ethyl]pyridine which was recrystallized from isopropanol to give 29.4 g. (54%) of the amino alcohol m.p. 126°-130° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04632992
Quelldatensatz	uspto-grants-1986_12
ORD ID	ord-e286de22e5854b9da3b1fae569df5f35
Quellennotiz	uspto-grants-1986_12