Hydrogen Sulfide → Ethyl thiazole-4-carboxylate

HRID 1249896Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1249896
[CH2:1]([O:3][C:4](=[O:12])[C:5]([N+:10]#[C-:11])=[CH:6]N(C)C)[CH3:2].C(N(CC)CC)C.[SH2:20]>O1CCCC1>[C:4]([C:5]1[N:10]=[CH:11][S:20][CH:6]=1)([O:3][CH2:1][CH3:2])=[O:12]

Komponenten

5

Edukt 3

HCID 402Hydrogen SulfideHCID 8471TriethylamineHCID 54355309Ethyl 3-(dimethylamino)-2-isocyanoacrylate

Produkt 1

HCID 5003096Ethyl thiazole-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 3-dimethylamino-2-isocyano-acrylic acid ethyl ester (1.0 g) and triethylamine (3.0 g) in tetrahydrofuran (30 mL) is treated with gaseous hydrogen sulfide until all starting material is consumed. The mixture is concentrated to an oil and purified by column chromatography using silica and 25% ethyl acetate-hexanes as the eluant. The purified material (0.61 g) is isolated as an oil.

Aufarbeitung

  1. customis consumed
  2. concentrationThe mixture is concentrated to an oil
  3. custompurified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-992998d4ecc344069a2d4cd2595917c0
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06335350B1

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