Hydrogen Peroxide → (S)-(+)-5-Hydroxy-2-(2-methylbutyloxy)benzonitrile

HRID 1250334Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1250334
[C:1]([C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C@@H:11]([CH3:14])[CH2:12][CH3:13])#[N:2].[OH:18]O>C1COCC1>[OH:18][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][C@@H:11]([CH3:14])[CH2:12][CH3:13])=[C:3]([CH:4]=1)[C:1]#[N:2]

Komponenten

4

Edukt 2

HCID 784Hydrogen PeroxideHCID 53923893(S)-(+)-3-Cyano-4-(2-methylbutyloxy)phenylboronic acid

Produkt 1

HCID 54230638(S)-(+)-5-Hydroxy-2-(2-methylbutyloxy)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of compound 47 (3.00 g, 0.014 mol), hydrogen peroxide (30% w/v, 150 ml) and THF (200 ml) was heated under reflux for 3 h. The water /THF mixture was removed in vacuo and the oily residue was dissolved in diethyl either and washed with water. The ether was dried (MgSO4) and evaporated in vacuo to give a viscous, fawn oil.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 3 h
  3. customThe water /THF mixture was removed in vacuo
  4. dissolutionthe oily residue was dissolved in diethyl either
  5. washwashed with water
  6. dry with materialThe ether was dried (MgSO4)
  7. customevaporated in vacuo
  8. customto give a viscous, fawn oil

Quellen und Nachweise

ORD-Eintrag
ord-64baf8365f004ee98d30cb4f09898af2
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06337420B1

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