Triethylamine → 2-Cyanoethoxy(4,5-dichloroimidazolyl)pyrrolidinophosphine

HRID 1250986

Reaktionsgleichung

Reaktionsgleichung von HRID 1250986
[Cl:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[Cl:7].C(N(CC)CC)C.Cl[P:16]([O:22][CH2:23][CH2:24][C:25]#[N:26])[N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1>C(Cl)Cl>[C:25]([CH2:24][CH2:23][O:22][P:16]([C:4]1[NH:3][C:2]([Cl:1])=[C:6]([Cl:7])[N:5]=1)[N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)#[N:26]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 1400184,5-DichloroimidazoleHCID 18325653Chloro(2-Cyanoethoxy) pyrrolidinophosphine

Produkt 1

HCID 183256522-Cyanoethoxy(4,5-dichloroimidazolyl)pyrrolidinophosphineAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 4,5-dichloroimidazole (1.59 g, 11.63 mmol) and triethylamine (1.95 mL, 1.41 g, 13.96 mmol) in CH2Cl2 (30 mL) was added dropwise Chloro(2-Cyanoethoxy) pyrrolidinophosphine (2.40 g, 11.63 mmol) in CH2Cl2 (10 mL) at room temperature. The mixture was stirred for 4 h at room temperature. The reaction mixture was filtered to remove the resulting salt, and the solvent was removed under reduced pressure to give the crude product as a pale yellow oil (2.93 g, 82%). 31P NMR (CDCl3) δ 123.2.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customto remove the resulting salt
  3. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b03eb36065c84d98b1929afdb42351e3
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06340749B1

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