Sodium Hydroxide → HCID 9856593, Verbindung

HRID 1251008Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1251008
[CH3:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:9]2[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5][C:4]=2[C:3]=1[C:17]([O:19]C)=[O:18].[OH-].[Na+]>C1COCC1>[CH3:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:9]2[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5][C:4]=2[C:3]=1[C:17]([OH:19])=[O:18]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 10588717HCID 10588717, Verbindung

Produkt 1

HCID 9856593HCID 9856593, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a suspension of 6-methyl-7-nitro-2,3-dioxo-1,2,3,4-tetrahydro-quinoxaline-5-carboxylic acid, methyl ester (0.80 g, 2.87 mmol) in THF (50 mL) was added aqueous 1.0N NaOH (4.3 mL, 4.3 mmol), and the reaction mixture was refluxed for 23 hours. The product is precipitated upon acidification with conc. HCL and recrystallized from water to give 0.73 g (96%).

Aufarbeitung

  1. temperaturethe reaction mixture was refluxed for 23 hours
  2. customThe product is precipitated upon acidification with conc. HCL
  3. customrecrystallized from water
  4. customto give 0.73 g (96%)

Quellen und Nachweise

ORD-Eintrag
ord-54e8e249a5524c0ca6c8a7aa9db7991b
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06340758B1

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