1-Ethylpiperazine → 6-Bromo-8-(1-ethylpiperazin-4-yl)-1,7-naphthyridine

HRID 1251157Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1251157
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10](Br)[N:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.[CH2:13]([N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[CH3:14]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([N:18]3[CH2:19][CH2:20][N:15]([CH2:13][CH3:14])[CH2:16][CH2:17]3)[N:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2

Komponenten

3

Edukt 2

HCID 791961-EthylpiperazineHCID 225032286,8-Dibromo-1,7-naphthyridine

Produkt 1

HCID 225032736-Bromo-8-(1-ethylpiperazin-4-yl)-1,7-naphthyridineAusbeute 98 %

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

6,8-Dibromo-1,7-naphthyridine (3.464 g) was added to 1-ethylpiperazine (10 ml), and the resulting mixture was stirred at 100° C. for 15 min. The reaction mixture was evaporated, and then partitioned between ethyl acetate and water. The resulting organic layer was washed with water, dried (over MgSO4) and evaporated. The resulting residue was purified by (NH) silica gel column chromatography (ethyl acetate/hexane system), to give the title compound as a yellowish orange solid (3.780 g, yield; 98%).

Aufarbeitung

  1. customThe reaction mixture was evaporated
  2. custompartitioned between ethyl acetate and water
  3. washThe resulting organic layer was washed with water
  4. dry with materialdried (over MgSO4)
  5. customevaporated
  6. customThe resulting residue was purified by (NH) silica gel column chromatography (ethyl acetate/hexane system)

Quellen und Nachweise

ORD-Eintrag
ord-b62cc567fc674a359b050b04cd825e19
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06340759B1

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