Triethylamine → 1-(4-Ethylpiperidin-1-yl)-3-(4-methoxyphenyl)isoquinolinehydrochloride

HRID 1251191

Reaktionsgleichung

[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=2)[N:3]=1.[CH2:20]([CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[CH3:21].C(N(CC)CC)C>CN(C)C=O>[ClH:1].[CH2:20]([CH:22]1[CH2:27][CH2:26][N:25]([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH:5]=[C:4]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)[N:3]=2)[CH2:24][CH2:23]1)[CH3:21]

Komponenten

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

1-Chloro-3-(4-methoxyphenyl)isoquinoline (405 mg) and 4-ethylpiperidine (168 mg) were dissolved in N,N-dimethylformamide (5 ml), followed by the addition of triethylamine (251 ml), and the mixture was stirred at 80° C. overnight. The reaction mixture was partitioned between ethyl acetate and water. The resulting organic layer was washed with water, dried (over MgSO4) and evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system). Then the resulting product was converted into a hydrochloride in a conventional manner, and then recrystallized from ethanol/isopropyl ether, to give the hydrochloride of the title compound as a colorless crystals (87 mg, yield; 13%).

Aufarbeitung

customThe reaction mixture was partitioned between ethyl acetate and water
washThe resulting organic layer was washed with water
dry with materialdried (over MgSO4)
customevaporated
customThe resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane system)
customrecrystallized from ethanol/isopropyl ether

Quellen und Nachweise

ORD-Eintrag: ord-3f5b38b17e854ce389fb9ea050bc662c
Quelldatensatz: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06340759B1

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