(+)-Pulegone → Pulegol

HRID 1251628Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1251628
[CH3:1][C@H:2]1[CH2:11][C:9](=[O:10])[C:5](=[C:6]([CH3:8])[CH3:7])[CH2:4][CH2:3]1.CC(O)C.NCCCN.CC(O)C.[OH-].[K+].[H][H]>CC(O)C>[CH3:1][CH:2]1[CH2:11][CH:9]([OH:10])[C:5](=[C:6]([CH3:7])[CH3:8])[CH2:4][CH2:3]1

Komponenten

6

Edukt 4

HCID 442495(+)-PulegoneHCID 183243451,3-Diaminopropane 2-propanolHCID 23443544KOH isopropanolHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 92793PulegolAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

A 100 ml capacity autoclave was charged with 3.04 g (20 mmol) of pulegone, 19.1 mg (0.02 mmol) of RuCl2(PPh3)3, 0.2 M 1,3-diaminopropane 2-propanol solution (0.2 ml), 0.2 M potassium hydroxide 2-propanol solution (1.0 ml) and 2-propanol (14 ml), and the mixture was stirred at 25° C. for 3 hours under a hydrogen pressure of 2 MPa. After completion of the reaction, hydrogen was purged, the reaction solution was concentrated and then distillation was carried out under a reduced pressure to obtain 2.61 g of pulegol. The yield was 85%.

Aufarbeitung

  1. customwas purged
  2. concentrationthe reaction solution was concentrated
  3. distillationdistillation

Quellen und Nachweise

ORD-Eintrag
ord-4965c9f16876497b9fcfa4c5f1b07a84
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06342644B1

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