(+)-Pulegone → Pulegol

HRID 1251629Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1251629
[CH3:1][C@H:2]1[CH2:11][C:9](=[O:10])[C:5](=[C:6]([CH3:8])[CH3:7])[CH2:4][CH2:3]1.CC([O-])(C)C.[K+].[H][H]>CC(O)C>[CH3:1][CH:2]1[CH2:11][CH:9]([OH:10])[C:5](=[C:6]([CH3:7])[CH3:8])[CH2:4][CH2:3]1

Komponenten

5

Edukt 3

HCID 442495(+)-PulegoneHCID 23665647Potassium tert-butoxideHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 92793PulegolAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
30 °C

Versuchsvorschrift

A 200 ml capacity autoclave was charged with 30.4 g (200 mmol) of pulegone, 19.1 mg (0.02 mmol) of RuCl2(PPh3)3(propanediamine), 44.9 mg (0.4 mmol) of t-BuOK and 2-propanol (15 ml), and the mixture was stirred at 30° C. for 18 hours while forcing 3 Mpa of hydrogen. After completion of the reaction, hydrogen was purged and the reaction solution was concentrated and distilled under a reduced pressure to obtain 30.2 g of pulegol. The yield was 98%.

Aufarbeitung

  1. customwas purged
  2. concentrationthe reaction solution was concentrated
  3. distillationdistilled under a reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-35fda5d58b8c49709da5c0377dab6a76
Quelldatensatz
uspto-grants-2002_01
Patentnummer
US06342644B1

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