Imidazole → 2-(Tert-butyldiphenylsilyloxymethyl)imidazole

Beteiligte Stoffe

Reaktionsschritte

A solution of 2-hydroxymethylimidazole (1.96 g ; 0.02 mole), imidazole (3.4 g; 0.05 mole), tert-butyldiphenylsilyl chloride (6.6 g; 0.024 mole) in DMF (20 ml) was stirred under an argon atmosphere for 16 hours. The mixture was extracted with ethyl acetate and purified by flash column chromatography eluting with a gradient 50-70% ethyl acetate/petroleum ether to give 2-(tert-butyldiphenylsilyloxymethyl)imidazole as a solid.

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