N-Vinylpyrrolidine → Ethyl 6-Phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

HRID 12520

Reaktionsgleichung

Reaktionsgleichung von HRID 12520
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2N=N[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[N:11][C:10]=2[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:5][CH:4]=1.[CH:28](N1CCCC1)=[CH2:29]>C(Cl)(Cl)Cl>[C:20]1([C:10]2[N:11]=[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:29]=[CH:28][C:9]=2[C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:27])([F:26])[F:1])=[CH:4][CH:5]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Komponenten

4

Edukt 2

HCID 3014294N-Vinylpyrrolidine2×HCID 59338837Ethyl 6-(4-trifluoromethylphenyl)-5-phenyl-1,2,4-triazine-3-carboxylate2×

Produkt 1

HCID 68408073Ethyl 6-Phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Following General Procedure D, ethyl 6-(4-trifluoromethylphenyl)-5-phenyl-1,2,4-triazine-3-carboxylate (Compound 15), (378 mg, 1.01 mmol) and crude 1-vinylpyrrolidine (Compound 38, 780 mg) in CHCl3 (10 ml) were reacted to produce the title compound as a yellow oil.

Aufarbeitung

  1. customwere reacted

Quellen und Nachweise

ORD-Eintrag
ord-e1ca332375e44a608fce6d0a24b1e328
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728014B2

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