Sodium Hydroxide → 4-[4-(3-Indolyl)piperidinomethyl]-2-glycoloylaminothiazole

HRID 1252079Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1252079
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[N:18]=[C:19]([NH:22][C:23](=[O:29])[CH2:24][O:25]C(=O)C)[S:20][CH:21]=3)[CH2:12][CH2:11]2)=[CH:2]1.[OH-].[Na+]>C(O)C>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][C:17]3[N:18]=[C:19]([NH:22][C:23](=[O:29])[CH2:24][OH:25])[S:20][CH:21]=3)[CH2:14][CH2:15]2)=[CH:2]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 141297994-[4-(3-Indolyl)piperidinomethyl]-2-(2-acetoxyacetylamino)thiazole

Produkt 1

HCID 141298054-[4-(3-Indolyl)piperidinomethyl]-2-glycoloylaminothiazoleAusbeute 34,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a suspension of 4-[4-(3-indolyl)piperidinomethyl]-2-(2-acetoxyacetylamino)thiazole (0.9 g) in ethanol (20 ml) was added 1N aqueous solution of sodium hydroxide (3 ml). After one hour of stirring, the reaction mixture was concentrated and the resulting precipitate was collected by filtration and recrystallized from a mixture of water and ethanol to give 4-[4-(3-indolyl)piperidinomethyl]-2-glycoloylaminothiazole (0.28 g).

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated
  2. filtrationthe resulting precipitate was collected by filtration
  3. customrecrystallized from a mixture of water and ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f8b177ca19dd43c4bacff1b125b8ecc9
Quelldatensatz
uspto-grants-1988_05
Patentnummer
US04742057

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