4-Methoxybenzyl alcohol → HCID 20140782, Verbindung

HRID 1252216

Reaktionsgleichung

Reaktionsgleichung von HRID 1252216
[CH3:1][C:2]1([CH3:10])[CH2:8][CH2:7][C:6](=[O:9])[O:5][C:3]1=[O:4].[OH:11][CH2:12][C:13]1[CH:20]=[CH:19][C:16]([O:17][CH3:18])=[CH:15][CH:14]=1.C(N(CC)CC)C>O1CCOCC1>[C:3]([C:2]([CH3:10])([CH3:1])[CH2:8][CH2:7][C:6]([O:11][CH2:12][C:13]1[CH:20]=[CH:19][C:16]([O:17][CH3:18])=[CH:15][CH:14]=1)=[O:9])([OH:5])=[O:4]

Komponenten

5

Edukt 3

HCID 77384-Methoxybenzyl alcoholHCID 8471TriethylamineHCID 76247Dihydro-3,3-dimethyl-2H-pyran-2,6(3H)-dione

Produkt 1

HCID 20140782HCID 20140782, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 2,2-dimethylglutaric anhydride (19.34 g), anise alcohol (22.08 g) and triethylamine (19.39 g) in dry dioxane (360 ml) was stirred at 80° C. for 3.5 hours. The reaction mixture was evaporated and the residue was diluted with water and adjusted to pH 9 with potassium carbonate. The aqueous layer was washed with benzene, acidified with dilute hydrochloric acid and extracted with benzene. The extract was washed with water, dried over anhydrous sodium sulfate and evaporated to give p-methoxybenzyl 4-carboxy-4-methylvalerate.

Aufarbeitung

  1. customThe reaction mixture was evaporated
  2. additionthe residue was diluted with water
  3. washThe aqueous layer was washed with benzene
  4. extractionextracted with benzene
  5. washThe extract was washed with water
  6. dry with materialdried over anhydrous sodium sulfate
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-b098b3b1ed444003b5fa770d4f851bf6
Quelldatensatz
uspto-grants-1988_05
Patentnummer
US04742052

Verknüpfte Notizen

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