Ethyl 6-Phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate → Methyl 6-Phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

HRID 12529

Reaktionsgleichung

Reaktionsgleichung von HRID 12529
[C:1]1([C:7]2[N:12]=[C:11]([C:13]([O:15][CH2:16]C)=[O:14])[CH:10]=[CH:9][C:8]=2[C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>OS(O)(=O)=O.CO>[C:1]1([C:7]2[N:12]=[C:11]([C:13]([O:15][CH3:16])=[O:14])[CH:10]=[CH:9][C:8]=2[C:18]2[CH:19]=[CH:20][C:21]([C:24]([F:27])([F:25])[F:26])=[CH:22][CH:23]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 1

HCID 68408073Ethyl 6-Phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate2×

Produkt 1

HCID 25033166Methyl 6-Phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1118Sulfuric AcidKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Following General Procedure E, ethyl 6-phenyl-5-(4-trifluoromethylphenyl)-pyridine-2-carboxylate (Compound 25, 110 mg, 0.29 mmol) and conc. H2SO4 (5 drops) in MeOH (5 ml) were reacted to produce the title compound as a white solid.

Aufarbeitung

  1. customwere reacted

Quellen und Nachweise

ORD-Eintrag
ord-c1134c48fb9443239d86e6435989bfb3
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728014B2

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