Dicyclohexylcarbodiimide → HCID 54399293, Verbindung

HRID 1252995

Reaktionsgleichung

Reaktionsgleichung von HRID 1252995
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([O:10][CH3:11])=[O:9])[CH:3]=1.[CH3:12][O:13][P:14]([CH2:18][C:19](O)=[O:20])([O:16][CH3:17])=[O:15].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[CH3:12][O:13][P:14]([CH2:18][C:19]([NH:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([O:10][CH3:11])=[O:9])[CH:3]=1)=[O:20])([O:16][CH3:17])=[O:15]

Komponenten

5

Edukt 3

HCID 10868DicyclohexylcarbodiimideHCID 1899642-(Dimethoxyphosphoryl)acetic acidHCID 3759117Methyl 4-aminopyridine-2-carboxylate

Produkt 1

HCID 54399293HCID 54399293, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 1.0 g of methyl 4-aminopicolinate, 1.0 g of α-(dimethylphosphono)-acetic acid and 1.0 g of dicyclohexylcarbodiimide in 10 ml of methylene chloride is stirred at room temperature for 6 hours. After filtration and removal of solvent the residue is chromatographed on silica gel with 5% methanol/methylene chloride as the eluent to afford methyl 4-(α-dimethylphosphonoacetamido)-picolinate as a viscous oil.

Aufarbeitung

  1. filtrationAfter filtration and removal of solvent the residue
  2. customis chromatographed on silica gel with 5% methanol/methylene chloride as the eluent

Quellen und Nachweise

ORD-Eintrag
ord-a2a22c313bd44465a2801eae875476c0
Quelldatensatz
uspto-grants-1988_05
Patentnummer
US04746653

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