Ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate → Methyl 5-Phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

HRID 12530Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 12530
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:23]([O:25][CH2:26]C)=[O:24])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>OS(O)(=O)=O.CO>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:23]([O:25][CH3:26])=[O:24])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:21])([F:22])[F:20])=[CH:15][CH:14]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 1

HCID 68407826Ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate2×

Produkt 1

HCID 59338840Methyl 5-Phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1118Sulfuric AcidKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Following General Procedure E, ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate (Compound 29, 103 mg, 0.28 mmol) and conc. H2SO4 (5 drops) in MeOH (5 ml) were reacted to produce the title compound as a white solid.

Aufarbeitung

  1. customwere reacted

Quellen und Nachweise

ORD-Eintrag
ord-3748fd020f36428fb4e075cc855cf526
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728014B2

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