Chloride → L-Proline, ethyl ester

HRID 1253494

Reaktionsgleichung

Reaktionsgleichung von HRID 1253494
[NH:1]1[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([OH:5])=[O:4].[Cl-].[CH3:10][CH2:11]O>>[NH:1]1[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([O:5][CH2:10][CH3:11])=[O:4]

Komponenten

4

Edukt 3

HCID 312ChlorideHCID 702EthanolHCID 145742L-Proline

Produkt 1

HCID 79888L-Proline, ethyl ester

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

Into a 500 ml 3-necked roundbottom flask, was placed a solution of proline (20.0 g, 174. mmol) in EtOH (100 ml). To the above was added thinyl chloride (40 ml). The resulting solution was heated to 70° C., with stirring, for 12 hours. The mixture was concentrated by evaporation. To afford ethyl prolinate that was used without further purification.

Aufarbeitung

  1. customInto a 500 ml 3-necked roundbottom flask, was placed
  2. concentrationThe mixture was concentrated by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-3e0e149d45424cc48db96ba50c681e26
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08455477B2

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