Trifluoroacetic acid → 8-(4-Fluorophenyl)-2,8-diazaspiro[4.5]decane

HRID 1253691

Reaktionsgleichung

Reaktionsgleichung von HRID 1253691
C(O)(C(F)(F)F)=O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:31][CH2:30][C:18]3([CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)[CH2:17][CH2:16]2)=[CH:11][CH:10]=1>C(Cl)Cl>[F:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:16][CH2:17][C:18]3([CH2:22][NH:21][CH2:20][CH2:19]3)[CH2:30][CH2:31]2)=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 66701232Tert-butyl 8-(4-fluorophenyl)-2,8-diazaspiro[4.5]decane-2-carboxylate

Produkt 1

HCID 595056788-(4-Fluorophenyl)-2,8-diazaspiro[4.5]decane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

TFA (0.6 ml) was added to a cooled (0° C.) solution of tert-butyl 8-(4-fluorophenyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (0.31 mmol, 1.0 eq.) in methylene chloride (2 ml) and the reaction mixture was stirred at 25° C. for 1 h. When the reaction was complete, the solvent was removed in vacuo in order to obtain the desired amine (AMN-22).

Aufarbeitung

  1. customthe solvent was removed in vacuo in order

Quellen und Nachweise

ORD-Eintrag
ord-8579a9116d994918b771f70eb9441161
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08455475B2

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