Trifluoroacetic acid → 2,2,2-Trifluoro-1-(2,8-diazaspiro[4.5]decan-8-yl)ethanone

HRID 1253750Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1253750
C(O)(C(F)(F)F)=O.[F:8][C:9]([F:30])([F:29])[C:10]([N:12]1[CH2:28][CH2:27][C:15]2([CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)[CH2:14][CH2:13]1)=[O:11]>>[F:30][C:9]([F:8])([F:29])[C:10]([N:12]1[CH2:28][CH2:27][C:15]2([CH2:19][NH:18][CH2:17][CH2:16]2)[CH2:14][CH2:13]1)=[O:11]

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59505224Tert-butyl 8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carboxylate

Produkt 1

HCID 595052392,2,2-Trifluoro-1-(2,8-diazaspiro[4.5]decan-8-yl)ethanone

Versuchsvorschrift

TFA (1 ml) was added to a stirred solution of tert-butyl 8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (840 mg, 2.5 mmol) in MC (4 ml) and the mixture was stirred at RT for 12 h. The reaction mixture was then concentrated under reduced pressure and azeotroped with MC (2×10 ml). The crude product was dried and used for the next step without further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customazeotroped with MC (2×10 ml)
  3. dry with materialThe crude product was dried
  4. customused for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-6793d3e5bd36422d9e469b9ee9667c7c
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08455475B2

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