Potassium Hydroxide → N-(6-(2,8-Diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)-2-chlorobenzamide

HRID 1253752Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1253752
[OH-].[K+].[Cl:3][C:4]1[CH:39]=[CH:38][CH:37]=[CH:36][C:5]=1[C:6]([NH:8][CH:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:18]([N:20]3[CH2:24][CH2:23][C:22]4([CH2:29][CH2:28][N:27](C(=O)C(F)(F)F)[CH2:26][CH2:25]4)[CH2:21]3)=[O:19])[CH:16]=2)[CH2:11][CH2:10]1)=[O:7]>CO>[CH2:21]1[C:22]2([CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:23][CH2:24][N:20]1[C:18]([C:15]1[CH:16]=[C:17]2[C:12]([CH2:11][CH2:10][CH:9]2[NH:8][C:6](=[O:7])[C:5]2[CH:36]=[CH:37][CH:38]=[CH:39][C:4]=2[Cl:3])=[CH:13][CH:14]=1)=[O:19]

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 595057192-Chloro-N-(6-(8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)benzamide

Produkt 1

HCID 59505509N-(6-(2,8-Diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)-2-chlorobenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2 M KOH solution (4 ml) was added to a stirred solution of 2-chloro-N-(6-(8-(2,2,2-trifluoroacetyl)-2,8-diazaspiro[4.5]decane-2-carbonyl)-2,3-dihydro-1H-inden-1-yl)benzamide (200 mg, 0.374 mmol, 1 eq.) in MeOH (4 ml) and the mixture was stirred for 5 h. Methanol was removed under reduced pressure and it was diluted with EtOAc (100 ml) and washed with water (10 ml) and brine (20 ml). The organic layer was dried over sodium sulfate, filtered and concentrated to dryness. The crude material was used for the next step without further purification.

Aufarbeitung

  1. customMethanol was removed under reduced pressure and it
  2. additionwas diluted with EtOAc (100 ml)
  3. washwashed with water (10 ml) and brine (20 ml)
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated to dryness
  7. customThe crude material was used for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-ae36efb8cde9449898537cc8f0716fb2
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08455475B2

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