Hydrogen Peroxide → 5-amino-1-cyclopentyl-1H-pyrazole-4-carboxamide

HRID 1253792

Reaktionsgleichung

Reaktionsgleichung von HRID 1253792
[OH:1]O.[NH2:3][C:4]1[N:8]([CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:14]#[N:15]>C(O)C.N>[NH2:3][C:4]1[N:8]([CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:14]([NH2:15])=[O:1]

Komponenten

5

Edukt 2

HCID 784Hydrogen PeroxideHCID 179603715-Amino-1-cyclopentyl-1H-pyrazole-4-carbonitrile

Produkt 1

HCID 117011915-amino-1-cyclopentyl-1H-pyrazole-4-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 222AmmoniaLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

85 ml of 30% strength hydrogen peroxide solution are added to a solution of 5-amino-1-cyclopentyl-1H-pyrazole-4-carbonitrile (6.74 g, 38.3 mmol) in a mixture of 300 ml of ethanol and 371 ml of concentrated aqueous ammonia solution at room temperature and stirred at room temperature overnight. The nonaqueous solvents are then stripped off in a rotary evaporator. The product precipitates as solid from the remaining mixture and is filtered off with suction, washed with diethyl ether and dried under high vacuum.

Aufarbeitung

  1. customThe nonaqueous solvents are then stripped off in a rotary evaporator
  2. customThe product precipitates as solid from the remaining mixture
  3. filtrationis filtered off with suction
  4. washwashed with diethyl ether
  5. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2c25040e8f5148d7bd8dac74c9d9ebc7
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08455502B2

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