4-(Trifluoromethyl)benzaldehyde → Ethyl 5-(4-ethylphenyl)-6-(4-(trifluoromethyl)phenyl)pyridine-2-carboxylate

HRID 12538

Reaktionsgleichung

[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1.[CH2:13]([O:15][C:16]([C:18](=[CH:39][CH:40]=[CH:41][C:42]1[CH:47]=[CH:46][C:45]([CH2:48][CH3:49])=[CH:44][CH:43]=1)[N:19]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:17])[CH3:14]>C(#N)C>[CH2:48]([C:45]1[CH:44]=[CH:43][C:42]([C:41]2[CH:40]=[CH:39][C:18]([C:16]([O:15][CH2:13][CH3:14])=[O:17])=[N:19][C:7]=2[C:6]2[CH:9]=[CH:10][C:3]([C:2]([F:12])([F:11])[F:1])=[CH:4][CH:5]=2)=[CH:47][CH:46]=1)[CH3:49]

Komponenten

Reaktionsbedingungen

Temperatur: 60 °C

Versuchsvorschrift

General Procedure K. 4-(trifluoromethyl)benzaldehyde (153 mg, 1.88 mmol) was added to a stirred solution of 3-ethoxycarbonyl-1,1,1-triphenyl-6-(4-ethylphenyl)-2-aza-1λ5-phosphahexa-1,3,5-triene (Compound 46, 444 mg, 0.88 mmol) in dry acetonitrile (10 ml) and the solution was heated to 60° C. for 18 hours. The solution was concentrated in vacuo, and the crude product was passed through a silica gel column with 15% ethyl acetate in hexane as eluant to give the title compound as a yellow oil.

Aufarbeitung

concentrationThe solution was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-12e19353160e48d3b4cc4a7e27d8621c
Quelldatensatz: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07728014B2

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