m-Chloroperbenzoic acid → HCID 67314368, Verbindung

HRID 1254083Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1254083
[CH3:1][C:2]1[N:7]=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1.ClC1C=C(C=CC=1)C(OO)=[O:17]>C(Cl)(Cl)Cl.ClCCl>[CH3:1][C:2]1[N+:7]([O-:17])=[C:6]2[CH2:8][O:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1

Komponenten

5

Edukt 2

HCID 70297m-Chloroperbenzoic acidHCID 58478770HCID 58478770, Verbindung

Produkt 1

HCID 67314368HCID 67314368, VerbindungAusbeute 73,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6212ChloroformLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 2-methyl-7H-furo[3,4-b]pyridin-5-one (150 mg, 1.0 mmol) in chloroform (5 mL) and dichloromethane (1 mL) is treated with m-chloroperoxybenzoic acid (258 mg, 1.5 mmol). The reaction mixture is stirred at room temperature overnight. The reaction mixture is concentrated and the residue is purified by chromatography (silica gel). The product containing fractions are concentrated to give the title compound as a solid (122 mg, 73%).

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated
  2. customthe residue is purified by chromatography (silica gel)
  3. additionThe product containing fractions
  4. concentrationare concentrated

Quellen und Nachweise

ORD-Eintrag
ord-c69c06a9357844abb74d7c552645d600
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08455535B2

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